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nmdcat.online July 11, 2026

A distinguishing characteristic of an irreversible inhibitor is that it

A. Binds to the active site and can be overcome by excess substrate
B. Forms a stable, covalent bond with a functional group essential for enzyme activity
✓
C. Decreases Vmax and proportionally decreases Km
D. Is a structural analog of the substrate

📝 Explanation

Irreversible inhibitors covalently modify essential residues or cofactors, leading to permanent enzyme inactivation.

📖 Additional Information

  • Binds to the active site and can be overcome by excess substrate
  • Forms a stable, covalent bond with a functional group essential for enzyme activity
  • Decreases Vmax and proportionally decreases Km
  • Is a structural analog of the substrate

Irreversible inhibitors covalently modify essential residues or cofactors, leading to permanent enzyme inactivation.

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