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nmdcat.online July 11, 2026

A mutation in the gene encoding a metabolic enzyme results in a complete loss of activity. The mutation is most likely in the region coding for amino acids that are

A. On the surface of the enzyme, far from the active site
B. Located in the hydrophobic core, responsible for maintaining solubility
C. Directly involved in forming the catalytic cleft and binding the substrate
✓
D. Part of a flexible loop region that can be cleaved off

📝 Explanation

A mutation in the small number of residues forming the active site would directly abolish enzyme function, unlike mutations in distant structural or surface regions.

📖 Additional Information

  • On the surface of the enzyme, far from the active site
  • Located in the hydrophobic core, responsible for maintaining solubility
  • Directly involved in forming the catalytic cleft and binding the substrate
  • Part of a flexible loop region that can be cleaved off

A mutation in the small number of residues forming the active site would directly abolish enzyme function, unlike mutations in distant structural or surface regions.

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