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nmdcat.online July 28, 2026

A patient is diagnosed with a condition that causes progressive destruction of the sarcoplasmic reticulum in their muscle tissues. Which muscle type would experience the most immediate and profound loss of function?

A. Smooth muscle
B. Cardiac muscle
C. Skeletal muscle
✓
D. Visceral muscle

📝 Explanation

Skeletal muscle is almost entirely dependent on the intracellular calcium stored in its highly developed sarcoplasmic reticulum (SR) for contraction. Cardiac and smooth muscles rely heavily on extracellular calcium and have less developed SRs, making them less immediately vulnerable to SR destruction.

📖 Additional Information

  • Smooth muscle
  • Cardiac muscle
  • Skeletal muscle
  • Visceral muscle

Skeletal muscle is almost entirely dependent on the intracellular calcium stored in its highly developed sarcoplasmic reticulum (SR) for contraction. Cardiac and smooth muscles rely heavily on extracellular calcium and have less developed SRs, making them less immediately vulnerable to SR destruction.

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