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nmdcat.online July 7, 2026

During continuous intense stimulation, the depletion of neurotransmitter stores in the presynaptic terminal leads to

A. Synaptic facilitation
B. Synaptic fatigue
✓
C. Spatial summation
D. Synaptic potentiation

📝 Explanation

Synaptic fatigue occurs when the rate of neurotransmitter release exceeds the rate of its synthesis and recycling, causing a temporary failure of synaptic transmission despite incoming action potentials.

📖 Additional Information

  • Synaptic facilitation
  • Synaptic fatigue
  • Spatial summation
  • Synaptic potentiation

Synaptic fatigue occurs when the rate of neurotransmitter release exceeds the rate of its synthesis and recycling, causing a temporary failure of synaptic transmission despite incoming action potentials.

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