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nmdcat.online June 27, 2026

In the structure of an antibody molecule, the region responsible for the vast diversity that allows binding to a specific antigen is the

A. Constant region of the heavy chain
B. Variable region at the amino-terminal end of both the light and heavy chains
✓
C. Transmembrane anchoring domain
D. The carbohydrate moiety attached to the Fc region

📝 Explanation

The amino-terminal ends of both the light (VL) and heavy (VH) chains form the antigen-binding site. These variable domains have highly diverse amino acid sequences from one antibody clone to another, creating a unique 3D surface that is specific for a single epitope.

📖 Additional Information

  • Constant region of the heavy chain
  • Variable region at the amino-terminal end of both the light and heavy chains
  • Transmembrane anchoring domain
  • The carbohydrate moiety attached to the Fc region

The amino-terminal ends of both the light (VL) and heavy (VH) chains form the antigen-binding site. These variable domains have highly diverse amino acid sequences from one antibody clone to another, creating a unique 3D surface that is specific for a single epitope.

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