The arrival of an action potential at the synaptic knob opens voltage-gated Ca²⁺ channels. The resulting Ca²⁺ influx causes synaptic vesicles to fuse with the presynaptic membrane and release their contents.
The arrival of an action potential at the synaptic knob opens voltage-gated Ca²⁺ channels. The resulting Ca²⁺ influx causes synaptic vesicles to fuse with the presynaptic membrane and release their contents.