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Practice Questions

In the mechanism of hearing, the fluid-filled channel of the cochlea that directly houses the organ of Corti is the

A. Scala vestibuli
B. Scala tympani
C. Cochlear duct (Scala media) ✓
D. Semicircular canal

The organ of Corti sits on the basilar membrane within the cochlear duct (scala media), which is filled with endolymph. The scala vestibuli and scala tympani contain perilymph.

nmdcat.online BIO NMDCAT
Jul 7, 2026

The encapsulated mechanoreceptors located in the dermal papillae that are highly sensitive to light touch and low-frequency vibration are

A. Pacinian corpuscles
B. Meissner's corpuscles ✓
C. Ruffini endings
D. Merkel discs

Meissner's corpuscles are rapidly adapting, encapsulated receptors found just beneath the epidermis in hairless skin, specializing in fine, discriminative touch.

nmdcat.online BIO NMDCAT
Jul 7, 2026

Regarding pain reception, the sensation of fast, sharp, and highly localized pain is transmitted to the CNS by

A. Unmyelinated C fibers
B. Myelinated A-delta fibers ✓
C. A-beta fibers
D. B fibers

Fast, sharp pain (like a needle prick) is transmitted rapidly by myelinated A-delta fibers. Slow, dull, aching pain is transmitted by unmyelinated C fibers.

nmdcat.online BIO NMDCAT
Jul 7, 2026

In the retina, the visual pigment rhodopsin relies heavily on the dietary intake of

A. Vitamin C
B. Vitamin K
C. Vitamin A ✓
D. Vitamin D

Rhodopsin consists of opsin protein bound to retinal. Retinal is a light-absorbing molecule synthesized directly from Vitamin A (retinol). Vitamin A deficiency leads to night blindness.

nmdcat.online BIO NMDCAT
Jul 7, 2026

During sensory transduction, a generator potential that reaches threshold directly triggers

A. Neurotransmitter release from the receptor cell
B. An action potential in the sensory axon ✓
C. The opening of mechanically-gated channels
D. Sensory adaptation

A generator potential is a graded depolarization in the sensory nerve ending itself. If it reaches threshold, it opens voltage-gated sodium channels at the first node of Ranvier, firing an action potential.

nmdcat.online BIO NMDCAT
Jul 7, 2026

The adequate stimulus for a specific sensory receptor is defined as the

A. Stimulus that produces the most intense sensation
B. Form of energy to which the receptor is most sensitive ✓
C. Minimum stimulus intensity required for detection
D. Only type of energy that can activate the receptor

The adequate stimulus is the specific form of energy (light, mechanical, chemical) to which a receptor is uniquely adapted and most sensitive, having the lowest threshold for activation. It is not the only energy that can activate it (e.g., a hard punch to the eye causes seeing "stars").

nmdcat.online BIO NMDCAT
Jul 7, 2026

75. In structural cytology, the target consequence of introducing an artificial molecule that competitively binds to kinetochores is the

A. Inability of spindle microtubules to attach and segregate chromosomes ✓
B. Complete structural disassembly of the nucleosome octamer cores
C. Spontaneous duplication of telomeric caps without replication loops
D. Hyper-activation of transcription complexes along euchromatin tracks

Blocking the kinetochores prevents microtubule attachment at the centromere, interrupting mitotic checkpoints and halting orderly chromosome separation.

nmdcat.online BIO NMDCAT
Jul 4, 2026

74. In structural cytology, the target consequence of introducing an artificial molecule that competitively binds to kinetochores is the

A. Inability of spindle microtubules to attach and segregate chromosomes ✓
B. Complete structural disassembly of the nucleosome octamer cores
C. Spontaneous duplication of telomeric caps without replication loops
D. Hyper-activation of transcription complexes along euchromatin tracks

Blocking the kinetochores prevents microtubule attachment at the centromere, interrupting mitotic checkpoints and halting orderly chromosome separation.

nmdcat.online BIO NMDCAT
Jul 4, 2026

73. In structural cytology, the target consequence of introducing an artificial molecule that competitively binds to kinetochores is the

A. Inability of spindle microtubules to attach and segregate chromosomes ✓
B. Complete structural disassembly of the nucleosome octamer cores
C. Spontaneous duplication of telomeric caps without replication loops
D. Hyper-activation of transcription complexes along euchromatin tracks

Blocking the kinetochores prevents microtubule attachment at the centromere, interrupting mitotic checkpoints and halting orderly chromosome separation.

nmdcat.online BIO NMDCAT
Jul 4, 2026

72. In structural cytology, the target consequence of introducing an artificial molecule that competitively binds to kinetochores is the

A. Inability of spindle microtubules to attach and segregate chromosomes ✓
B. Complete structural disassembly of the nucleosome octamer cores
C. Spontaneous duplication of telomeric caps without replication loops
D. Hyper-activation of transcription complexes along euchromatin tracks

Blocking the kinetochores prevents microtubule attachment at the centromere, interrupting mitotic checkpoints and halting orderly chromosome separation.

nmdcat.online BIO NMDCAT
Jul 4, 2026

71. In structural cytology, the target consequence of introducing an artificial molecule that competitively binds to kinetochores is the

A. Inability of spindle microtubules to attach and segregate chromosomes ✓
B. Complete structural disassembly of the nucleosome octamer cores
C. Spontaneous duplication of telomeric caps without replication loops
D. Hyper-activation of transcription complexes along euchromatin tracks

Blocking the kinetochores prevents microtubule attachment at the centromere, interrupting mitotic checkpoints and halting orderly chromosome separation.

nmdcat.online BIO NMDCAT
Jul 4, 2026

70. In structural cytology, the target consequence of introducing an artificial molecule that competitively binds to kinetochores is the

A. Inability of spindle microtubules to attach and segregate chromosomes ✓
B. Complete structural disassembly of the nucleosome octamer cores
C. Spontaneous duplication of telomeric caps without replication loops
D. Hyper-activation of transcription complexes along euchromatin tracks

Blocking the kinetochores prevents microtubule attachment at the centromere, interrupting mitotic checkpoints and halting orderly chromosome separation.

nmdcat.online BIO NMDCAT
Jul 4, 2026

69. In structural cytology, the target consequence of introducing an artificial molecule that competitively binds to kinetochores is the

A. Inability of spindle microtubules to attach and segregate chromosomes ✓
B. Complete structural disassembly of the nucleosome octamer cores
C. Spontaneous duplication of telomeric caps without replication loops
D. Hyper-activation of transcription complexes along euchromatin tracks

Blocking the kinetochores prevents microtubule attachment at the centromere, interrupting mitotic checkpoints and halting orderly chromosome separation.

nmdcat.online BIO NMDCAT
Jul 4, 2026

68. In structural cytology, the target consequence of introducing an artificial molecule that competitively binds to kinetochores is the

A. Inability of spindle microtubules to attach and segregate chromosomes ✓
B. Complete structural disassembly of the nucleosome octamer cores
C. Spontaneous duplication of telomeric caps without replication loops
D. Hyper-activation of transcription complexes along euchromatin tracks

Blocking the kinetochores prevents microtubule attachment at the centromere, interrupting mitotic checkpoints and halting orderly chromosome separation.

nmdcat.online BIO NMDCAT
Jul 4, 2026

67. In structural cytology, the target consequence of introducing an artificial molecule that competitively binds to kinetochores is the

A. Inability of spindle microtubules to attach and segregate chromosomes ✓
B. Complete structural disassembly of the nucleosome octamer cores
C. Spontaneous duplication of telomeric caps without replication loops
D. Hyper-activation of transcription complexes along euchromatin tracks

Blocking the kinetochores prevents microtubule attachment at the centromere, interrupting mitotic checkpoints and halting orderly chromosome separation.

nmdcat.online BIO NMDCAT
Jul 4, 2026

66. In structural cytology, the target consequence of introducing an artificial molecule that competitively binds to kinetochores is the

A. Inability of spindle microtubules to attach and segregate chromosomes ✓
B. Complete structural disassembly of the nucleosome octamer cores
C. Spontaneous duplication of telomeric caps without replication loops
D. Hyper-activation of transcription complexes along euchromatin tracks

Blocking the kinetochores prevents microtubule attachment at the centromere, interrupting mitotic checkpoints and halting orderly chromosome separation.

nmdcat.online BIO NMDCAT
Jul 4, 2026

65. In structural cytology, the target consequence of introducing an artificial molecule that competitively binds to kinetochores is the

A. Inability of spindle microtubules to attach and segregate chromosomes ✓
B. Complete structural disassembly of the nucleosome octamer cores
C. Spontaneous duplication of telomeric caps without replication loops
D. Hyper-activation of transcription complexes along euchromatin tracks

Blocking the kinetochores prevents microtubule attachment at the centromere, interrupting mitotic checkpoints and halting orderly chromosome separation.

nmdcat.online BIO NMDCAT
Jul 4, 2026

64. Regarding chromatin classification, heterochromatin is functionally distinguished from euchromatin by its property of being

A. Tightly condensed and transcriptionally inactive ✓
B. Enriched with high amounts of structural mRNA molecules
C. Completely devoid of core histone octamers
D. Replicated exclusively during early G1 cell phase

Heterochromatin remains heavily condensed throughout the cell cycle and contains dense, methylated DNA sequences that are mostly transcriptionally silent.

nmdcat.online BIO NMDCAT
Jul 4, 2026

63. The numerical stability of the diploid chromosome complement across consecutive somatic generations is structurally guaranteed by

A. Random crossing over in prophase
B. Precise DNA replication followed by mitotic chromosome segregation ✓
C. The continuous activity of reverse transcriptase
D. Alternative splicing of structural histone pre-mRNAs

Somatic chromosome consistency relies on high-fidelity DNA replication during S-phase followed by symmetrical separation of sister chromatids to daughter nuclei during mitosis.

nmdcat.online BIO NMDCAT
Jul 4, 2026
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