BIO NMDCAT Sexually transmitted diseases

nmdcat.online July 16, 2026

The human immunodeficiency virus (HIV) specifically binds to CD4 receptors. In addition to T-helper cells, which of the following cell types also expresses CD4 and can serve as a viral reservoir in mucosal tissues during sexual transmission?

A. Macrophages

✓

B. Erythrocytes

C. Neurons

D. Skeletal muscle cells

📝 Explanation

The correct option is Macrophages. Macrophages (and dendritic cells) also express the CD4 receptor and CCR5 coreceptor. They are often the first cells infected in mucosal tissues during sexual transmission and act as reservoirs carrying the virus to lymph nodes.

📖 Additional Information

Macrophages
Erythrocytes
Neurons
Skeletal muscle cells

The correct option is Macrophages. Macrophages (and dendritic cells) also express the CD4 receptor and CCR5 coreceptor. They are often the first cells infected in mucosal tissues during sexual transmission and act as reservoirs carrying the virus to lymph nodes.

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