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nmdcat.online July 11, 2026

The most appropriate explanation for why a very high temperature causes a permanent decrease in the reaction rate is that

A. The excessive kinetic energy prevents the formation of the enzyme-substrate complex
B. The enzyme undergoes denaturation, losing its native three-dimensional structure
✓
C. The substrate molecules undergo a conformational change
D. The coenzymes decompose at high temperatures

📝 Explanation

High temperatures disrupt non-covalent bonds (e.g., hydrogen bonds) stabilizing protein structure, causing irreversible unfolding (denaturation) and loss of active site shape.

📖 Additional Information

  • The excessive kinetic energy prevents the formation of the enzyme-substrate complex
  • The enzyme undergoes denaturation, losing its native three-dimensional structure
  • The substrate molecules undergo a conformational change
  • The coenzymes decompose at high temperatures

High temperatures disrupt non-covalent bonds (e.g., hydrogen bonds) stabilizing protein structure, causing irreversible unfolding (denaturation) and loss of active site shape.

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