BIO NMDCAT Muscles
nmdcat.online July 28, 2026

The observed experimental result of blocking the enzyme acetylcholinesterase at a neuromuscular junction would be:

A. Immediate relaxation of the skeletal muscle fiber
B. Failure of the somatic motor neuron to release acetylcholine
C. Sustained contraction or spasms of the skeletal muscle fiber
D. Decreased permeability of the sarcolemma to sodium ions

📝 Explanation

Acetylcholinesterase breaks down acetylcholine (ACh) in the synaptic cleft, allowing the muscle to relax. If blocked, ACh remains in the cleft, continuously binding to receptors and causing sustained depolarization and continuous muscle contraction (spasms/tetanus).

📖 Additional Information

  • Immediate relaxation of the skeletal muscle fiber
  • Failure of the somatic motor neuron to release acetylcholine
  • Sustained contraction or spasms of the skeletal muscle fiber
  • Decreased permeability of the sarcolemma to sodium ions

Acetylcholinesterase breaks down acetylcholine (ACh) in the synaptic cleft, allowing the muscle to relax. If blocked, ACh remains in the cleft, continuously binding to receptors and causing sustained depolarization and continuous muscle contraction (spasms/tetanus).

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