Acetylcholinesterase breaks down acetylcholine (ACh) in the synaptic cleft, allowing the muscle to relax. If blocked, ACh remains in the cleft, continuously binding to receptors and causing sustained depolarization and continuous muscle contraction (spasms/tetanus).
Acetylcholinesterase breaks down acetylcholine (ACh) in the synaptic cleft, allowing the muscle to relax. If blocked, ACh remains in the cleft, continuously binding to receptors and causing sustained depolarization and continuous muscle contraction (spasms/tetanus).