The principal inhibitory neurotransmitter in the mammalian central nervous system is

A. Glutamate

B. Gamma-aminobutyric acid (GABA)

✓

C. Substance P

D. Nitric oxide

📝 Explanation

GABA is the major inhibitory neurotransmitter in the brain, functioning primarily by opening chloride channels on postsynaptic neurons to induce hyperpolarization. Glutamate is the major excitatory neurotransmitter.

📖 Additional Information

Glutamate
Gamma-aminobutyric acid (GABA)
Substance P
Nitric oxide

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