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BIO NMDCAT ENZYMES
nmdcat.online July 11, 2026

The reaction exhibiting an optimal pH that reflects the ionization state of active site residues, rather than a global denaturation effect, suggests that

A. The enzyme is a ribozyme
B. Catalysis depends critically on the protonation state of specific amino acid R-groups
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C. The enzyme has an absolute requirement for a metal ion
D. The substrate can only bind when it is in a fully uncharged state

📝 Explanation

Bell-shaped pH-activity profiles often reflect the ionization of catalytic residues that must be in a specific protonation state to function as acid/base catalysts.

📖 Additional Information

  • The enzyme is a ribozyme
  • Catalysis depends critically on the protonation state of specific amino acid R-groups
  • The enzyme has an absolute requirement for a metal ion
  • The substrate can only bind when it is in a fully uncharged state

Bell-shaped pH-activity profiles often reflect the ionization of catalytic residues that must be in a specific protonation state to function as acid/base catalysts.

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