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BIO NMDCAT Sexually transmitted diseases
nmdcat.online July 16, 2026

Which of the following best describes the pathogenesis of gumma formation in the tertiary stage of syphilis?

A. Direct viral destruction of host epithelial cells
B. Granulomatous lesions resulting from hypersensitivity reactions to remaining spirochetes
✓
C. Accumulation of purulent exudate due to massive neutrophil influx
D. Rapid bacterial replication causing tissue necrosis

📝 Explanation

The correct option is Granulomatous lesions resulting from hypersensitivity reactions to remaining spirochetes. Gummas are soft, non-cancerous granulomatous growths that characterize tertiary syphilis. They are essentially a destructive delayed hypersensitivity immune response to localized persistent spirochete antigens.

📖 Additional Information

  • Direct viral destruction of host epithelial cells
  • Granulomatous lesions resulting from hypersensitivity reactions to remaining spirochetes
  • Accumulation of purulent exudate due to massive neutrophil influx
  • Rapid bacterial replication causing tissue necrosis

The correct option is Granulomatous lesions resulting from hypersensitivity reactions to remaining spirochetes. Gummas are soft, non-cancerous granulomatous growths that characterize tertiary syphilis. They are essentially a destructive delayed hypersensitivity immune response to localized persistent spirochete antigens.

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