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nmdcat.online July 4, 2026

19. Experimental treatment of a dividing cell line with a specific drug that inhibits the enzymatic activity of telomerase results in a downstream effect characterized by

A. Immediate expansion of the nucleolar organizer regions
B. Progressive shortening of chromosome ends leading to replicative senescence
✓
C. Total conversion of all heterochromatin into euchromatin loops
D. The loss of basic arginine residues from core histones

📝 Explanation

Telomerase maintains telomere length. Inhibiting it leaves the cell unable to synthesize telomeric repeats, causing progressive chromosome shortening with each replication cycle until cellular senescence is triggered.

📖 Additional Information

  • Immediate expansion of the nucleolar organizer regions
  • Progressive shortening of chromosome ends leading to replicative senescence
  • Total conversion of all heterochromatin into euchromatin loops
  • The loss of basic arginine residues from core histones

Telomerase maintains telomere length. Inhibiting it leaves the cell unable to synthesize telomeric repeats, causing progressive chromosome shortening with each replication cycle until cellular senescence is triggered.

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