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nmdcat.online July 4, 2026

20. A molecular mutation that eliminates the positive charge from the basic tail sequences of core histone proteins would directly lead to a cellular state featuring

A. Hyper-condensation of the chromatin fiber arrays
B. De-condensation of DNA due to lost electrostatic affinity for histones
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C. Rapid acceleration of mitotic spindle fiber contraction
D. Selective degradation of satellite body non-coding segments

📝 Explanation

The positive charges on histones neutralize the negative DNA backbone. Removing these charges disrupts the attractive forces, leading to chromatin de-condensation and a breakdown of higher-order chromosome packaging.

📖 Additional Information

  • Hyper-condensation of the chromatin fiber arrays
  • De-condensation of DNA due to lost electrostatic affinity for histones
  • Rapid acceleration of mitotic spindle fiber contraction
  • Selective degradation of satellite body non-coding segments

The positive charges on histones neutralize the negative DNA backbone. Removing these charges disrupts the attractive forces, leading to chromatin de-condensation and a breakdown of higher-order chromosome packaging.

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