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BIO NMDCAT Conjugated molecules
nmdcat.online July 3, 2026

86. An experimental cell line exhibits a mutation resulting in a total loss of the enzyme phosphomannose isomerase. Biochemically, this defect leads to the failure of N-linked glycosylation. The immediate pathobiological outcome for the secreted proteins in this cell system will be

A. Their conversion into functional cytoplasmic glycolipids
B. Their retention in the endoplasmic reticulum due to misfolding and accelerated degradation
✓
C. Spontaneous export as highly active structural catalysts
D. Their structural conversion into double-stranded nucleoproteins

📝 Explanation

Unmodified or poorly glycosylated proteins fail the ER quality control check, remain bound to chaperones, and are targeted for ER-associated degradation (ERAD).

📖 Additional Information

  • Their conversion into functional cytoplasmic glycolipids
  • Their retention in the endoplasmic reticulum due to misfolding and accelerated degradation
  • Spontaneous export as highly active structural catalysts
  • Their structural conversion into double-stranded nucleoproteins

Unmodified or poorly glycosylated proteins fail the ER quality control check, remain bound to chaperones, and are targeted for ER-associated degradation (ERAD).

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