90. A patient presents with xanthomas and severe hyperlipidemia. Genetic testing reveals a complete loss-of-function mutation in the gene encoding apolipoprotein C-II (ApoC-II). The molecular explanation for the patient’s pathological inability to clear triacylglycerols from the blood is that ApoC-II is the obligatory activator for
A.
Hepatic glycogen synthase
B.
Capillary endothelial lipoprotein lipase
✓
C.
Nuclear RNA Polymerase I
D.
Lysosomal hexosaminidase A
📝 Explanation
Lipoprotein lipase requires ApoC-II as a co-factor to bind and hydrolyze triacylglycerols within chylomicrons and VLDLs.
📖 Additional Information
Hepatic glycogen synthase
Capillary endothelial lipoprotein lipase
Nuclear RNA Polymerase I
Lysosomal hexosaminidase A
Lipoprotein lipase requires ApoC-II as a co-factor to bind and hydrolyze triacylglycerols within chylomicrons and VLDLs.
