nmdcat.online
BIO NMDCAT Conjugated molecules
nmdcat.online July 3, 2026

91. The molecular mechanism of the drug Tunicamycin involves acting as a structural analog of UDP-GlcNAc, thereby inhibiting the enzyme GlcNAc phosphotransferase. The introduction of this drug blocks the very first step of

A. O-linked glycosylation in the Golgi
B. Synthesis of the dolichol-linked oligosaccharide core in N-linked glycosylation
✓
C. Assembly of apolipoproteins onto chylomicrons
D. Wrapping of DNA around the histone nucleoprotein core

📝 Explanation

Tunicamycin blocks the transfer of N-acetylglucosamine-1-phosphate onto dolichol phosphate, halting the assembly of the core sugar chain.

📖 Additional Information

  • O-linked glycosylation in the Golgi
  • Synthesis of the dolichol-linked oligosaccharide core in N-linked glycosylation
  • Assembly of apolipoproteins onto chylomicrons
  • Wrapping of DNA around the histone nucleoprotein core

Tunicamycin blocks the transfer of N-acetylglucosamine-1-phosphate onto dolichol phosphate, halting the assembly of the core sugar chain.

🔗 Share This Question

Facebook Twitter LinkedIn WhatsApp

🧭 Navigate Questions

Previous Question

90. A patient presents with xanthomas and severe hyperlipidemia. Genetic testing reveals a complete loss-of-function mutation in the gene encoding apolipoprotein C-II (ApoC-II). The molecular explanation for the patient's pathological inability to clear triacylglycerols from the blood is that ApoC-II is the obligatory activator for

Next Question

92. The selective modification of intracellular proteins with a single O-linked N-acetylglucosamine molecule (O-GlcNAcylation) on serine or threonine residues functions as a metabolic sensor because the substrate for this reaction, UDP-GlcNAc, is synthesized via the

Back to All Questions

🔗 Related MCQs

An increase in the incidence of ectopic pregnancies within a population can often be epidemiologically correlated with a prior increase in the prevalence of which sexually transmitted disease?
July 16, 2026
In the life cycle of Herpes Simplex Virus 2 (HSV-2), the virus travels along nerve fibers to reach the sensory ganglia. The cellular mechanism responsible for this retrograde transport utilizes:
July 16, 2026
A defining characteristic of the lesions associated with the secondary stage of syphilis is that they:
July 16, 2026
The causative agent of genital herpes, HSV-2, is enveloped. The biological significance of this viral envelope in the context of transmission is that it makes the virus:
July 16, 2026
The structural basis for the severe cardiovascular complications seen in tertiary syphilis, such as aortic aneurysms, is the chronic inflammation and destruction of:
July 16, 2026

Categories

View all →