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BIO NMDCAT Ribonucleic acid (RNA)
nmdcat.online July 3, 2026

92. The selective inhibition of the enzyme poly-A polymerase in a eukaryotic cell line would lead to the accumulation of cytoplasmic transcripts that are

A. Structurally normal but restricted to the nucleolus
B. Highly unstable and rapidly degraded by exonucleases
✓
C. Incapable of undergoing alternative splicing mechanisms
D. Selectively translated at abnormally accelerated rates

📝 Explanation

Without a protective 3' poly-A tail, newly exported cytoplasmic mRNA molecules are quickly targeted and broken down by cellular exonucleases.

📖 Additional Information

  • Structurally normal but restricted to the nucleolus
  • Highly unstable and rapidly degraded by exonucleases
  • Incapable of undergoing alternative splicing mechanisms
  • Selectively translated at abnormally accelerated rates

Without a protective 3' poly-A tail, newly exported cytoplasmic mRNA molecules are quickly targeted and broken down by cellular exonucleases.

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