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BIO NMDCAT Ribonucleic acid (RNA)
nmdcat.online July 3, 2026

93. During the process of transcription elongation, the temporary RNA-DNA hybrid helix within the transcription bubble adopts a structural geometry that is

A. Distinctly B-form, matching the native double-stranded DNA template
B. Specifically A-form, induced by the structural configuration of the ribose sugar
✓
C. Completely Z-form, characterized by a left-handed helical twist
D. Completely linear, preventing any base-stacking interactions

📝 Explanation

The 2'-OH group on the ribose ring structurally prevents the RNA-DNA hybrid from matching the B-form geometry, forcing it into an A-form configuration.

📖 Additional Information

  • Distinctly B-form, matching the native double-stranded DNA template
  • Specifically A-form, induced by the structural configuration of the ribose sugar
  • Completely Z-form, characterized by a left-handed helical twist
  • Completely linear, preventing any base-stacking interactions

The 2'-OH group on the ribose ring structurally prevents the RNA-DNA hybrid from matching the B-form geometry, forcing it into an A-form configuration.

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