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BIO NMDCAT Conjugated molecules
nmdcat.online July 3, 2026

92. The selective modification of intracellular proteins with a single O-linked N-acetylglucosamine molecule (O-GlcNAcylation) on serine or threonine residues functions as a metabolic sensor because the substrate for this reaction, UDP-GlcNAc, is synthesized via the

A. Hexosamine biosynthetic pathway integrating glucose, amino acid, fatty acid, and nucleotide metabolism
✓
B. Light-dependent reactions of the chloroplast grana
C. Direct transcription of structural nuclear genes
D. Complete beta-oxidation of long-chain sphingolipids

📝 Explanation

UDP-GlcNAc synthesis requires glucose, glutamine, acetyl-CoA, and UTP, making its concentrations highly responsive to overall cellular nutrient status.

📖 Additional Information

  • Hexosamine biosynthetic pathway integrating glucose, amino acid, fatty acid, and nucleotide metabolism
  • Light-dependent reactions of the chloroplast grana
  • Direct transcription of structural nuclear genes
  • Complete beta-oxidation of long-chain sphingolipids

UDP-GlcNAc synthesis requires glucose, glutamine, acetyl-CoA, and UTP, making its concentrations highly responsive to overall cellular nutrient status.

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