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nmdcat.online July 7, 2026

A drug that blocks voltage-gated sodium channels in the axonal membrane would immediately cause

A. Enhanced action potential propagation
B. Increased neurotransmitter release
C. Failure to generate action potentials
✓
D. Prolonged depolarization

📝 Explanation

Drugs like local anesthetics (e.g., lidocaine) or neurotoxins (e.g., tetrodotoxin) block voltage-gated Na⁺ channels, preventing the massive sodium influx required to generate and propagate an action potential.

📖 Additional Information

  • Enhanced action potential propagation
  • Increased neurotransmitter release
  • Failure to generate action potentials
  • Prolonged depolarization

Drugs like local anesthetics (e.g., lidocaine) or neurotoxins (e.g., tetrodotoxin) block voltage-gated Na⁺ channels, preventing the massive sodium influx required to generate and propagate an action potential.

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