BIO NMDCAT Neurons
nmdcat.online July 7, 2026

The main mechanism for the removal of serotonin and dopamine from the synaptic cleft is

A. Enzymatic degradation exclusively
B. Reuptake into the presynaptic terminal
C. Passive diffusion into the bloodstream
D. Phagocytosis by microglia

📝 Explanation

Unlike acetylcholine which is destroyed by enzymes, monoamine neurotransmitters (like serotonin, dopamine, and norepinephrine) are primarily cleared by active reuptake transporters bringing them back into the presynaptic knob.

📖 Additional Information

  • Enzymatic degradation exclusively
  • Reuptake into the presynaptic terminal
  • Passive diffusion into the bloodstream
  • Phagocytosis by microglia

Unlike acetylcholine which is destroyed by enzymes, monoamine neurotransmitters (like serotonin, dopamine, and norepinephrine) are primarily cleared by active reuptake transporters bringing them back into the presynaptic knob.

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