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BIO NMDCAT Sexually transmitted diseases
nmdcat.online July 16, 2026

A researcher studying Neisseria gonorrhoeae observes that mutant strains lacking functional fimbriae (pili) fail to cause disease in animal models. The observed experimental result suggests that fimbriae are essential for:

A. Intracellular survival within macrophages
B. Initial attachment and colonization of mucosal epithelia
✓
C. Penetration into the systemic circulation
D. Toxin production

📝 Explanation

The correct option is Initial attachment and colonization of mucosal epithelia. The experiment directly links the presence of fimbriae with pathogenicity. Fimbriae are virulence factors required to firmly adhere to the host mucosal cells, preventing the bacteria from being washed away.

📖 Additional Information

  • Intracellular survival within macrophages
  • Initial attachment and colonization of mucosal epithelia
  • Penetration into the systemic circulation
  • Toxin production

The correct option is Initial attachment and colonization of mucosal epithelia. The experiment directly links the presence of fimbriae with pathogenicity. Fimbriae are virulence factors required to firmly adhere to the host mucosal cells, preventing the bacteria from being washed away.

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