In skeletal muscle, calcium binds to troponin on the actin filament to expose binding sites. In smooth muscle, calcium binds to calmodulin in the cytosol, which then directly activates an enzyme (myosin light-chain kinase) that phosphorylates the myosin head to initiate contraction.
In skeletal muscle, calcium binds to troponin on the actin filament to expose binding sites. In smooth muscle, calcium binds to calmodulin in the cytosol, which then directly activates an enzyme (myosin light-chain kinase) that phosphorylates the myosin head to initiate contraction.