BIO NMDCAT Muscles
nmdcat.online July 28, 2026

The characteristic feature of the calcium-binding protein in smooth muscle is that, unlike the calcium-binding protein in skeletal muscle, it:

A. Is permanently attached to the actin filament
B. Directly activates an enzyme that phosphorylates myosin
C. Inhibits the binding of myosin to actin until calcium is removed
D. Is located entirely within the sarcoplasmic reticulum

📝 Explanation

In skeletal muscle, calcium binds to troponin on the actin filament to expose binding sites. In smooth muscle, calcium binds to calmodulin in the cytosol, which then directly activates an enzyme (myosin light-chain kinase) that phosphorylates the myosin head to initiate contraction.

📖 Additional Information

  • Is permanently attached to the actin filament
  • Directly activates an enzyme that phosphorylates myosin
  • Inhibits the binding of myosin to actin until calcium is removed
  • Is located entirely within the sarcoplasmic reticulum

In skeletal muscle, calcium binds to troponin on the actin filament to expose binding sites. In smooth muscle, calcium binds to calmodulin in the cytosol, which then directly activates an enzyme (myosin light-chain kinase) that phosphorylates the myosin head to initiate contraction.

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