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BIO NMDCAT Sexually transmitted diseases
nmdcat.online July 16, 2026

Which of the following experimental or diagnostic observations would definitively confirm a case of tertiary neurosyphilis rather than a primary infection?

A. Observation of spirochetes on dark-field microscopy of a genital ulcer
B. Positive specific treponemal antibodies in cerebrospinal fluid (CSF)
✓
C. Presence of a generalized maculopapular skin rash
D. Finding Gram-negative diplococci in urethral pus

📝 Explanation

The correct option is Positive specific treponemal antibodies in cerebrospinal fluid (CSF). Neurosyphilis involves central nervous system invasion. Examining the CSF for elevated proteins, white blood cells, and positive syphilis serology confirms tertiary neurosyphilis.

📖 Additional Information

  • Observation of spirochetes on dark-field microscopy of a genital ulcer
  • Positive specific treponemal antibodies in cerebrospinal fluid (CSF)
  • Presence of a generalized maculopapular skin rash
  • Finding Gram-negative diplococci in urethral pus

The correct option is Positive specific treponemal antibodies in cerebrospinal fluid (CSF). Neurosyphilis involves central nervous system invasion. Examining the CSF for elevated proteins, white blood cells, and positive syphilis serology confirms tertiary neurosyphilis.

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