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BIO NMDCAT Sexually transmitted diseases
nmdcat.online July 16, 2026

Among the following clinical manifestations, the distinguishing feature that differentiates the genital ulcer of herpes simplex virus (HSV) from the primary chancre of syphilis is:

A. The HSV ulcer is highly infectious
B. The HSV ulcer is painless
C. The HSV ulcer is deeply indurated
D. The HSV ulcer is preceded by painful fluid-filled vesicles
✓

📝 Explanation

The correct option is The HSV ulcer is preceded by painful fluid-filled vesicles. Genital herpes begins as painful vesicles (blisters) that rupture to form painful, shallow ulcers. The syphilitic chancre is a single, painless, firm (indurated) ulcer without a vesicular stage.

📖 Additional Information

  • The HSV ulcer is highly infectious
  • The HSV ulcer is painless
  • The HSV ulcer is deeply indurated
  • The HSV ulcer is preceded by painful fluid-filled vesicles

The correct option is The HSV ulcer is preceded by painful fluid-filled vesicles. Genital herpes begins as painful vesicles (blisters) that rupture to form painful, shallow ulcers. The syphilitic chancre is a single, painless, firm (indurated) ulcer without a vesicular stage.

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