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Practice Questions

37. The molecule known as ceruloplasmin, which carries copper ions in the blood plasma, belongs to the class of

A. Lipoproteins
B. Metalloproteins ✓
C. Nucleoproteins
D. Glycolipids

Ceruloplasmin is a specialized transport protein and enzyme that binds copper ions tightly, making it a conjugated metalloprotein.

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36. The functional consequence of a bacterial cell producing capsule-associated glycoproteins is enhanced

A. Resistance against host phagocytosis ✓
B. Susceptibility to penicillin antibiotics
C. Rate of binary fission division
D. Ability to fix atmospheric nitrogen

Scurrying pathogens use hydrophilic, slippery glycoprotein capsules to hide their surface markers and evade immune cell engulfment.

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As VLDL unloads triacylglycerols into adipose tissues via lipoprotein lipase, it becomes denser and transforms into cholesterol-rich LDL.

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34. The major conjugated molecule present in the extracellular matrix of cartilage that provides compressive strength and elasticity is a

A. Nucleoprotein complex
B. Proteoglycan aggregate ✓
C. Lipopolysaccharide sheet
D. Pure fibrous elastin

Proteoglycans form large aggregates with hyaluronic acid in cartilage, trapping water molecules to resist mechanical compression.

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33. An increase in the concentration of blood plasma lipoproteins containing the highest percentage of proteins by weight results in

A. Enhanced removal of arterial cholesterol plaques ✓
B. Rapid acceleration of plaque formation in coronary vessels
C. Fatal clotting of the pulmonary vein pathways
D. Decreased transport of fat-soluble vitamins

High-density lipoproteins (HDL) have the highest protein-to-lipid ratio and act to clear excess cholesterol from the circulatory pathways.

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32. The structural organization of the tobacco mosaic virus (TMV) represents a classic example of a conjugated

A. Glycolipid
B. Nucleoprotein ✓
C. Lipoprotein
D. Metalloprotein

TMV consists of a single strand of genomic RNA wrapped in a helical coat of capsomere proteins, forming a pure nucleoprotein.

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31. The function of chylomicrons synthesized by the mucosal cells of the small intestine is to transport

A. Dietary lipids via the lymphatic and circulatory systems ✓
B. Nuclear DNA from enterocytes to leukocytes
C. Glycogen directly to the skeletal muscle tissues
D. Heavy metal ions out of the digestive tract

Chylomicrons are large lipoproteins that absorb and transport dietary triacylglycerols and cholesterol from the intestines into lacteals.

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30. The biochemical analysis of the substance known as interferon shows it is a conjugated molecule classified as a

A. Lipoprotein
B. Glycoprotein ✓
C. Nucleoprotein
D. Phosphoprotein

Interferons are signaling proteins (cytokines) released by host cells in response to viral pathogens, and they are glycoproteins.

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29. The modification where a carbohydrate chain is attached to the hydroxyl oxygen of a serine or threonine residue is termed

A. N-linked glycosylation
B. O-linked glycosylation ✓
C. Esterification
D. Deamination

O-linked glycosylation occurs through the covalent attachment of an oligosaccharide to the oxygen atom of serine or threonine side chains.

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28. The biochemical feature that allows certain viruses, such as Influenza or HIV, to bind specifically to human host cell surfaces is their surface

A. Naked double-stranded DNA core
B. Envelope glycoproteins ✓
C. Internal nucleoprotein matrix
D. Phospholipid bilayer without markers

Viral envelope glycoproteins interact with host cell-surface receptors, mediating viral attachment and entry.

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27. The non-protein component of the conjugated molecule known as cytochrome c is a heme group containing an iron atom that changes its valency to facilitate

A. Peptide bond polymerization
B. Electron transport during cellular respiration ✓
C. Hydrolysis of complex starch polymers
D. Transcription of ribosomal structural genes

Cytochromes are electron-transporting metalloproteins whose iron center alternates between Fe2+ and Fe3+ states to transfer electrons.

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26. The specific class of lipoproteins associated with an elevated risk of atheroma formation and cardiovascular disease due to cholesterol deposition is

A. Chylomicrons
B. High-density lipoproteins (HDL)
C. Low-density lipoproteins (LDL) ✓
D. Very high-density lipoproteins (VHDL)

LDL transports cholesterol from the liver to peripheral tissues; excess circulating LDL can oxidize and deposit in arterial walls.

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25. The structural consequence of attaching a hydrophilic carbohydrate cluster to a hydrophobic membrane protein anchor is that the molecule becomes

A. Completely water-soluble
B. Amphipathic ✓
C. Unstable and prone to degradation
D. Non-functional

The molecule develops dual properties: a hydrophobic domain anchored in the lipid bilayer and a hydrophilic domain exposed to water.

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24. The presence of gangliosides, which are complex glycolipids containing sialic acid, is functionally vital within the

A. Outer cell wall of Gram-positive bacteria
B. Synaptic membranes of central nervous system neurons ✓
C. Inner cristae membrane of active mitochondria
D. Matrix of bone tissue lamellae

Gangliosides are abundant in nerve cell membranes, where they participate in cell signaling, myelin stability, and synaptogenesis.

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23. The introduction of a chemical that blocks the formation of lipoprotein complexes inside hepatic cells will lead to the

A. Accelerated export of bile pigments
B. Pathological accumulation of lipids inside the liver (fatty liver) ✓
C. Rapid breakdown of structural glycogen storage
D. Sudden reduction in blood glucose levels

Liver cells require protein synthesis to form VLDLs; blocking this prevents lipid export, causing fats to accumulate internally.

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22. The modification where a carbohydrate chain is linked to the amide nitrogen of an asparagine residue in a protein is called

A. O-linked glycosylation
B. N-linked glycosylation ✓
C. Lipidation
D. Phosphorylation

N-linked glycosylation targets the nitrogen atom on the side chain of an asparagine residue within a specific consensus sequence.

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21. The biochemical reason why nucleoproteins like chromosomes migrate toward the positive anode during gel electrophoresis is the

A. Basic nature of the histone core proteins
B. Negative charge of the phosphate groups on the associated DNA ✓
C. Presence of neutral carbohydrate markers
D. Hydrophobic nature of the nuclear membrane

Even when bound to basic proteins, the dense phosphate backbone of the DNA molecule provides a strong net negative charge to chromatin.

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20. The interaction between high-density lipoproteins (HDL) and peripheral tissue cells is medically beneficial because HDL

A. Deposits cholesterol into arterial walls
B. Transports excess cholesterol back to the liver for excretion ✓
C. Synthesizes novel fatty acid chains from glucose
D. Stores triacylglycerols inside adipocytes

HDL participates in reverse cholesterol transport, clearing excess lipids from blood vessels and carrying them back to the hepatic tissue.

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19. The structural distinction between a glycoprotein and a proteoglycan is that a proteoglycan contains

A. More lipid than carbohydrate
B. A higher percentage of carbohydrate, primarily composed of long glycosaminoglycan chains ✓
C. No covalent bonds between its parts
D. An exclusively intranuclear function

Proteoglycans are mostly carbohydrate by weight (80%–95%), containing long unbranched GAG chains, unlike standard glycoproteins.

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