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BIO NMDCAT Sexually transmitted diseases
nmdcat.online July 16, 2026

Regarding viral sexually transmitted diseases, which of the following pathogens establishes lifelong latency in the sacral sensory ganglia and causes recurrent outbreaks of painful vesicular lesions?

A. Neisseria gonorrhoeae
B. Human Immunodeficiency Virus (HIV)
C. Herpes Simplex Virus type 2 (HSV-2)
✓
D. Treponema pallidum

📝 Explanation

The correct option is Herpes Simplex Virus type 2 (HSV-2). HSV-2 infects epithelial cells and then travels retrogradely up sensory nerve fibers to reside latently in the sacral ganglia. Stress or immunosuppression can trigger anterograde transport and recurrent painful blisters.

📖 Additional Information

  • Neisseria gonorrhoeae
  • Human Immunodeficiency Virus (HIV)
  • Herpes Simplex Virus type 2 (HSV-2)
  • Treponema pallidum

The correct option is Herpes Simplex Virus type 2 (HSV-2). HSV-2 infects epithelial cells and then travels retrogradely up sensory nerve fibers to reside latently in the sacral ganglia. Stress or immunosuppression can trigger anterograde transport and recurrent painful blisters.

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