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Pathophysiology-II

197 questions found

Practice Questions

34. A patient with Addison’s disease (adrenal insufficiency) presents with fatigue, weakness, weight loss, and hyperpigmentation. What is the technical primary pathophysiological defect?

A. Excess cortisol production.
B. Autoimmune destruction of the adrenal cortex, leading to deficiency of cortisol and aldosterone.
C. Excess aldosterone production.
D. Impaired glucose metabolism.
nmdcat.online BS Nursing
Jun 6, 2026

35. A patient with severe pneumonia develops significant hypoxemia and increased work of breathing. What is the technical primary pathophysiological mechanism leading to hypoxemia in pneumonia?

A. Bronchoconstriction.
B. Alveolar consolidation with pus and exudate, impairing gas exchange.
C. Pulmonary embolism.
D. Reduced cardiac output.
nmdcat.online BS Nursing
Jun 6, 2026

36. A medicinal approach to managing Type 2 Diabetes Mellitus often involves metformin. What is the technical primary pathophysiological mechanism of action of metformin?

A. Increases insulin secretion from the pancreas.
B. Decreases hepatic glucose production and increases insulin sensitivity.
C. Delays glucose absorption from the gut.
D. Increases glucose excretion in the urine.
nmdcat.online BS Nursing
Jun 6, 2026

37. A patient presents with sudden onset of severe abdominal pain, rigidity, and rebound tenderness, following a history of peptic ulcer disease. What is the critical underlying pathophysiological event?

A. Appendicitis.
B. Gastroenteritis.
C. Perforation of a peptic ulcer, leading to peritonitis.
D. Irritable bowel syndrome exacerbation.
nmdcat.online BS Nursing
Jun 6, 2026

38. A patient with chronic heart failure takes an ACE inhibitor and a beta-blocker. From a medicinal perspective, what is the technical pathophysiological rationale for using a beta-blocker in chronic heart failure?

A. To increase heart rate.
B. To block the effects of sympathetic nervous system activation, reducing myocardial oxygen demand and improving cardiac remodeling.
C. To increase preload.
D. To dilate peripheral blood vessels.
nmdcat.online BS Nursing
Jun 6, 2026
nmdcat.online BS Nursing
Jun 6, 2026

40. A patient with acute kidney injury develops hyperkalemia. What is the urgent clinical concern and critical pathophysiological consequence of severe hyperkalemia?

A. Hypoglycemia.
B. Cardiac arrhythmias and potential cardiac arrest.
C. Hypotension.
D. Metabolic alkalosis.
nmdcat.online BS Nursing
Jun 6, 2026

41. A patient with liver cirrhosis develops hepatic encephalopathy, characterized by confusion, asterixis, and altered mental status. What is the technical primary pathophysiological mechanism causing this complication?

A. Accumulation of glucose in the brain.
B. Impaired detoxification of ammonia and other neurotoxins by the liver.
C. Cerebral ischemia.
D. Electrolyte imbalance.
nmdcat.online BS Nursing
Jun 6, 2026

26. A 25-year-old male with a history of recurrent infections, particularly pneumonia, presents with chronic productive cough, bronchiectasis on CT scan, and steatorrhea. What is the technical primary pathophysiological defect in cystic fibrosis?

A. Abnormal chloride channel function, leading to thick, viscous secretions.
B. Impaired ciliary movement.
C. Alveolar destruction.
D. Bronchial hypersensitivity.
nmdcat.online BS Nursing
Jun 6, 2026

42. A patient with osteoarthiritis experiences joint pain and stiffness, especially with movement, worsening over the day. From a technical pathophysiological perspective, osteoarthritis is characterized by:

A. Autoimmune inflammation of the synovial membrane.
B. Degeneration of articular cartilage.
C. Deposition of uric acid crystals.
D. Bacterial infection of the joint.
nmdcat.online BS Nursing
Jun 6, 2026

27. A patient presents with acute onset of severe low back pain, unilateral flank pain, and hematuria. Imaging reveals a kidney stone obstructing the ureter. What is the technical pathophysiological mechanism causing the pain?

A. Direct inflammation of the renal parenchyma.
B. Distension of the renal capsule and ureteral spasm.
C. Ischemia of the kidney.
D. Nerve compression in the spinal cord.
nmdcat.online BS Nursing
Jun 6, 2026

43. A patient with acute myocardial infarction (MI) is given aspirin. From a medicinal perspective, what is the technical pathophysiological mechanism of aspirin in this context?

A. Increases blood pressure.
B. Inhibits platelet aggregation and thrombus formation.
C. Directly dilates coronary arteries.
D. Increases myocardial contractility.
nmdcat.online BS Nursing
Jun 6, 2026

28. A patient with chronic obstructive pulmonary disease (COPD) develops acute respiratory failure with hypercapnia and hypoxemia. What is the critical clinical urgency in managing this patient?

A. Administering high-flow oxygen.
B. Initiating non-invasive positive pressure ventilation (NIPPV) or mechanical ventilation.
C. Encouraging deep breathing exercises.
D. Prescribing oral antibiotics.
nmdcat.online BS Nursing
Jun 6, 2026

29. A patient with a history of uncontrolled hypertension develops acute renal failure. From a technical pathophysiological perspective, what is the most likely cause of intra-renal acute kidney injury (AKI) in this context?

A. Hypovolemia.
B. Bilateral ureteral obstruction.
C. Acute tubular necrosis (ATN) due to prolonged renal ischemia.
D. Glomerulonephritis.
nmdcat.online BS Nursing
Jun 6, 2026

45. A patient with severe sepsis develops disseminated intravascular coagulation (DIC). What is the critical clinical urgency in managing DIC?

A. Administering large volumes of intravenous fluids.
B. Promptly treating the underlying cause of sepsis and managing bleeding/thrombosis.
C. Performing immediate surgery.
D. Providing only symptomatic relief.
nmdcat.online BS Nursing
Jun 6, 2026
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